Effect of BCG vaccination on the progression of latent tuberculosis infection to active disease in contacts: a systematic review and meta-analysis
BCG vaccination was associated with a significantly lower risk of LTBI progression to active TB, with the strength of this association varying by geographic region and age. These findings highlight the need to consider regional TB burden and age-specific factors when formulating vaccination policies.
Authors
- Yi Yang (ORCID: https://orcid.org/0000-0002-8247-7042)
- Guozhong Zhou (ORCID: https://orcid.org/0000-0002-4069-1796)
- Xinhua Cun
- Yingchen Zhou (ORCID: https://orcid.org/0000-0001-7615-6157)
- H X Chen
- Xin Guo (ORCID: https://orcid.org/0000-0003-4436-8387)
- Xiang Li (ORCID: https://orcid.org/0009-0004-0987-289X)
- Shunli Cai
- Jian He
- Tianwei Yan
- Yuan Xia
- Qingtao Tan
Institutions
- Kunming University of Science and Technology (CN)
- Kunming University (CN)
- Kunming Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- Kunming Third People's Hospital (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s12879-025-12318-y
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00