Distinct astrocyte phenotypes aid microglia‐mediated Aβ clearance in immunized Alzheimer's disease patients
We identify a unique astrocyte phenotype induced by Aβ immunization in AD, marked by high CHI3L1 expression. This astrocyte state may be driven by microglia at Aβ plaques and contribute to plaque clearance. Our findings highlight distinct astrocyte responses to Aβ immunization, shedding light on their role in therapeutic outcomes.
Authors
- Joshua Kuruvilla
- Ann Forsyth (ORCID: https://orcid.org/0000-0002-8400-6842)
- David Gate (ORCID: https://orcid.org/0000-0003-0481-9657)
- Pouya Jamshidi (ORCID: https://orcid.org/0000-0002-2038-8589)
- Brooke Simonton (ORCID: https://orcid.org/0000-0002-1366-1268)
- James A. R. Nicoll (ORCID: https://orcid.org/0000-0002-9444-7246)
- Lynn van Olst (ORCID: https://orcid.org/0000-0001-7569-0470)
- Delphine Boche
- Rudolph J Castellani
- Lily Camp
- Alex J Edwards
Institutions
- Northwestern University (US)
- National Institute on Drug Abuse (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- University of Southampton (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100543
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00