Role of acute alcohol‐induced acetylation in tauopathy

These findings indicate that alcohol-induced disruptions in brain acetylation may accelerate cognitive decline through epigenetic changes and impaired tau turnover. Females may be more susceptible to alcohol-accelerated tauopathy due to elevated tau acetylation, potentially impairing protein degradation. Future studies will explore the effects of chronic alcohol consumption on tauopathy and whether alcohol accelerates tauopathy via histone acetylation-mediated transcriptional changes in tau degradation pathways.