Cerebrovascular Reactivity in Older Adults with Enlarged Perivascular Spaces and White Matter Hyperintensities
We explored the contribution of CVR to ePVS and WMH distinctly. These findings suggest that higher CVR substantially decreases risk of having combined WMH and ePVS-CS. CVR deficits may represent early-stage changes which contribute to the development of both ePVS-CS and WMH. The cross-sectional design of this study limits examination of directionality or bidirectionality. Future studies could explore how regional differences in CVR are associated with each pathology and whether that may differentially affect cognitive functioning in the long-term.
Authors
- Daniel A. Nation (ORCID: https://orcid.org/0000-0002-9123-0658)
- Fatemah Shenasa (ORCID: https://orcid.org/0000-0001-9030-4857)
- Allison C Engstrom (ORCID: https://orcid.org/0000-0002-4676-0430)
- Shubir Dutt (ORCID: https://orcid.org/0000-0002-8408-2220)
- Xingfeng Shao (ORCID: https://orcid.org/0000-0002-4130-6204)
- Trevor Lohman (ORCID: https://orcid.org/0000-0002-9634-702X)
- John Paul M Alitin (ORCID: https://orcid.org/0009-0001-5494-9639)
- Amy Nguyen (ORCID: https://orcid.org/0000-0002-5939-9306)
- Arunima Kapoor (ORCID: https://orcid.org/0000-0003-4622-8951)
- Aimée Gaubert (ORCID: https://orcid.org/0000-0001-6812-522X)
- Danny JJ Wang
Institutions
- University of Southern California (US)
- University of California, San Francisco (US)
- University of California, Irvine (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098096
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00