Age‐ and sex‐effects on tau PET binding in the absence of beta‐amyloid pathology
Tau PET is sensitive to age-related tau accumulation and reveals a distribution pattern consistent with the neuropathological features of PART. Women consistently show higher tracer uptake across multiple brain regions suggesting previously reported increases in tau-burden for females is not merely an implication of AD pathology, but may reflect a widespread, intrinsic phenomenon. Notable age-associated increases in the basal ganglia are areas known for off target binding. A deeper understanding of the influences of age and sex on tracer uptake is essential for accurate interpretation of imaging data, particularly in distinguishing normal aging from disease related changes.
Authors
- Nicole S. McKay (ORCID: https://orcid.org/0000-0003-4123-2548)
- Hillary Protas (ORCID: https://orcid.org/0000-0003-2974-8998)
- Julie K. Wisch (ORCID: https://orcid.org/0000-0003-3624-2784)
- Sarah Keefe (ORCID: https://orcid.org/0000-0002-5943-0940)
- Diana A. Hobbs (ORCID: https://orcid.org/0000-0001-7822-6411)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Russ C. Hornbeck (ORCID: https://orcid.org/0000-0002-9519-6223)
- Erin E. Franklin
- Shaney Flores
- Chengjie Xiong
- Richard J. Perrin
- John C. Morris
- Brian A. Gordon
- Yi Su
- Tammie L.S. Benzinger
Institutions
- Washington University in St. Louis (US)
- Banner Alzheimer’s Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098038
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00