Gene immunotherapy regulated by astrocytic reactivity in a mouse model of amyloidosis
These results suggest that the GFAP promoter could control the production of therapeutics, such as rSol, in response to amyloid-induced astrocytic reactivity. Long-term studies will assess whether rSol prevents Aβ pathology progression in Tg-Aβ mice.
Authors
- Chinaza Lilian Dibia (ORCID: https://orcid.org/0000-0002-7306-8087)
- Nathalie Vacaresse
- Isabelle Aubert (ORCID: https://orcid.org/0000-0001-5163-9961)
- Luis Fernando Rubio‐Atonal
- Brandy Laurette
- Dildare Yurtsever
- Rikke Han Kofoed
Institutions
- University of Waterloo (CA)
- University of Toronto (CA)
- Aarhus University Hospital (DK)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103554
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00