Genetic and Social Determinants of Cognitive Decline in Black Older Adults: Exploring the Role of APOE‐TOMM40‐‘523 Haplotypes, Discrimination, and Loneliness
Social factors did not influence the effect of TOMM40-'523 on cognitive decline, but the effects of discrimination and loneliness on baseline cognition varied by APOE-genotype, and discrimination predicted cognitive decline in APOE-ε4+ carriers only. These findings suggest that APOE-ε4+ carriers may be vulnerable to the negative effects of discrimination on cognitive decline.
Authors
- Paris AJ Adkins‐Jackson
- Lauren Brown (ORCID: https://orcid.org/0000-0002-1681-8267)
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Kacie Deters
- Cristian Mojica
- Chima I. Ezeh
- April Denise Thames (ORCID: https://orcid.org/0000-0001-8414-7189)
- Lisa Laverne Barnes
- Katelyn Elizabeth Mooney
- Elizabeth Rose Mayeda
- Tanisha G Hill‐Jarrett
- Courtney Thomas Tobin
Institutions
- University of Southern California (US)
- Rush University Medical Center (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Columbia University Irving Medical Center (US)
- Institute on Aging (US)
- Fielding Graduate University (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105774
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00