Decline in adaptive immune responses within human leptomeningesduring Alzheimer's Disease progression
Our findings point to a concomitant leptomeningeal and brain parenchymal dysfunction of humoral immunity associated with worsened AD pathology, suggesting a target for systemic immune therapy.
Authors
- Katherine M. Sheu (ORCID: https://orcid.org/0000-0002-3811-3356)
- Na Sun (ORCID: https://orcid.org/0000-0001-9936-6907)
- Mitchell H. Murdock (ORCID: https://orcid.org/0000-0001-8625-624X)
- Li‐Huei Tsai
- Manolis Kellis
Institutions
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102245
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00