Mild premorbid intellectual impairment as a resilience factor in Down syndrome associated Alzheimer's disease

Cognitive decline timing and slope differ depending on PII level, but AD biomarker pathology does not. If cognition is used for staging or endpoints in clinical trials, then PII should be considered.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_099392
Primary Topic
Down syndrome and intellectual disability research
Type
article
Field-Weighted Citation Impact
0.00
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article

Mild premorbid intellectual impairment as a resilience factor in Down syndrome associated Alzheimer's disease

James Tyler Kennedy
Alzheimer s & Dementia
Down syndrome and intellectual disability research
article

Mild premorbid intellectual impairment as a resilience factor in Down syndrome associated Alzheimer's disease

James Tyler Kennedy
article en

Abstract

Cognitive decline timing and slope differ depending on PII level, but AD biomarker pathology does not. If cognition is used for staging or endpoints in clinical trials, then PII should be considered.

Alzheimer s & DementiaVol. 21(S2)
Washington University in St. Louis (US)
Openalex Percentile: Top 27%
Down syndrome and intellectual disability research
DOIOpen Access PDFOpenAlex
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Mild premorbid intellectual impairment as a resilience factor in Down syndrome associated Alzheimer's disease — James Tyler Kennedy · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS