Biological age predicts dementia and Alzheimer's disease plasma biomarker levels
We demonstrated that biological age is a predictor of AD pathology in preclinical and clinical stages, and we will next evaluate biological age acceleration as a predictor of pathology. In addition, we will be replicating all biomarker associations in brain by testing associations with autopsy measures of neuropathology. Future directions will include conducting models stratified by sex and by APOE-ε4 carrier status to identify if the relationship between biological aging and AD biomarkers is modulated by biological sex or APOE-ε4 genotype.
Authors
- Martin Medrano (ORCID: https://orcid.org/0000-0003-3673-9088)
- Clifton L. Dalgard (ORCID: https://orcid.org/0000-0003-2025-8239)
- Diones Rivera Mejía (ORCID: https://orcid.org/0000-0001-5935-8005)
- R. Lantigua
- Marielba Zerlin‐Esteves
- Jaclyn M. Eissman (ORCID: https://orcid.org/0000-0001-6439-3999)
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Angel Piriz
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0000-0003-3572-8248)
- Min N Qiao
- R Mayeux
- Vrinda Kalia
- Saurabh Dubey
- Renu Nandakumar
- Gary W Miller
- Lawrence S. Honig
- Badri N. Vardarajan
- Yiyi Ma
Institutions
- Uniformed Services University of the Health Sciences (US)
- Pontificia Universidad Católica Madre y Maestra (DO)
- Instituto Tecnológico de Santo Domingo (DO)
- Universidad Nacional Pedro Henríquez Ureña (DO)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107627
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00