Differential expression of conditioned medium from tauopathies patients' olfactory neuroepithelial precursor cells, implications in the neurodegeneration

The differential expression of trophic factors released by hONE-NPCs in AD and PSP patients is significant compared to apparently healthy participants. These trophic factors are linked to signaling pathways involved in cellular proliferation and survival. This reduction directly impacts cellular proliferation and survival, as demonstrated by phenotypic characterization, showing decreased Ki67 expression relative to the total number of DAPI-stained cells. To date, no studies have focused on the conditioned media or the changes in trophic factors during tauopathies, such as Alzheimer's disease dementia and PSP, in primary cultures of human olfactory neuroepithelial progenitor cells, opening a new research avenue.