Female‐Specific Molecular Dysregulation in Alzheimer's Disease: miRNA and Gene Dynamics in 3xTg‐AD Mice
This study highlighted the vulnerability of female 3xTg-AD mice at 3 months of age, marked by amyloidogenic miRNA dysregulation and differential gene expression in the neocortex-hippocampus. However, sex-specific differences in miRNA and gene expression diminished with aging.
Authors
- Joanne A. Matsubara (ORCID: https://orcid.org/0000-0002-6236-9191)
- Matthew E. Campbell (ORCID: https://orcid.org/0000-0003-3325-240X)
- Jeanne Xi
- Wellington Pham (ORCID: https://orcid.org/0000-0002-8408-7611)
- Si Chen (ORCID: https://orcid.org/0000-0002-4196-0740)
- Printha Wijesinghe
Institutions
- Vancouver Coastal Health (CA)
- University of British Columbia (CA)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100545
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00