Relationship Between Amyloid Beta Deposition and Gene Expression Patterns in Alzheimer's Disease
Our study provides evidence that the spatial expression patterns of downregulated risk genes underlie the in vivo Aβ deposition patterns in AD. These imaging-transcriptomic findings have the potential to guide the development of molecular and genetic network-based therapeutic approaches for AD.
Authors
- Junyin Lu
- Ling Xiao
- Yongxiang Tang (ORCID: https://orcid.org/0009-0005-9649-2656)
- Xuewen Xiao
- Bin Jiao
- Lu Shen
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100138
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00