New insights and predictability from in vivo recordings of paroxysmal sympathetic hyperactivity in disorders of consciousness
HRV analysis reveals distinct autonomic signatures preceding PSH and suggests, as a working hypothesis, that dysregulation of the RAAS may play a role. However, VLF power is influenced by multiple mechanisms and cannot be considered a specific or exclusive marker of RAAS activity. SVM-based predictive modeling offers a promising tool for PSH detection, providing a basis for investigating autonomic/neuroendocrine regulation, including RAAS.
Authors
- Lucia Francesca Lucca (ORCID: https://orcid.org/0000-0002-7602-2711)
- Francesco Riganello (ORCID: https://orcid.org/0000-0003-0678-9252)
- Martina Vatrano (ORCID: https://orcid.org/0000-0003-4423-440X)
- Andrea Soddu (ORCID: https://orcid.org/0000-0001-6833-745X)
- Elio Leto
- Maria Daniela Cortese (ORCID: https://orcid.org/0000-0002-8524-6581)
- Maria Ursino
- Antonio Cerasa
- Maria Elena Pugliese
- Nicholas Schiff
Institutions
- Western University (CA)
- Cornell University (US)
- Istituto S.Anna Crotone (IT)
- Institute for Biomedical Research and Innovation (IT)
Publication Details
- Journal
- Clinical Autonomic Research
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1007/s10286-025-01175-z
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00