Mitochondrial Dysfunction in Down Syndrome associated Alzheimer's Disease
We describe profound mitochondrial dysfunction in human postmortem brain from DSAD individuals which is recapitulated in cerebral organoid models. Mitochondrial fractions also show increased APP accumulation.
Authors
- Cynthia Shaddy‐Gouvion
- Mohammad Haeri (ORCID: https://orcid.org/0000-0001-6055-9779)
- Keith P. Smith (ORCID: https://orcid.org/0000-0003-2672-6339)
- Brittany M Hauger
- Elizabeth Head
- Taylor A. Strope
- Heather M Wilkins
Institutions
- Alzheimer's Association (US)
- University of Kansas (US)
- University of California, Irvine (US)
- Rainbow Medical (Israel) (IL)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106248
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00