Plasma Alzheimer's mass spectrometry biomarkers associated with cerebrospinal fluid dynamics
Understanding how CSF dynamics affect plasma biomarkers is critical for implementation. The relationship between lower Aβ42 and DESH is expected based on prior CSF studies, which can be addressed by using an amyloid ratio. p-tau217 shows robustness against DESH, making it a suitable biomarker in cases of abnormal cerebrospinal fluid dynamics although validation in a more severe CSF dynamics group is warranted.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jeffrey L. Gunter (ORCID: https://orcid.org/0000-0001-7813-9078)
- Ekaterina I. Hofrenning (ORCID: https://orcid.org/0000-0003-2266-6746)
- Jonathan Graff‐Radford
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Camilo Bermudez (ORCID: https://orcid.org/0000-0002-9461-5094)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Petrice M Cogswell
- David S. Knopman
- Benjamin D Elder
- Ronald Petersen
- Neill R. Graff‐Radford
- David T. Jones
Institutions
- Jacksonville College (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101248
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00