Sleep Deprivation is associated with autophagic impairment and Alzheimer's‐related pathology in the orexinergic ‐ locus coeruleus ‐ hippocampal circuit

We identify that both acute and chronic sleep disruption can impair autophagic function in the orexinergic and LC sleep-regulating regions, negatively impacting behavior. We further note linkages to stress and sex-based differences that are relevant to the etiology of AD and may represent the need for targeted approaches to treatment in the future.