Adult global deletion of C1q reduces reactive astrocytes and rescues synaptic loss independently of amyloid phagocytosis in AD mouse model
The data presented here demonstrates that global deletion of C1q in the Arctic mouse model results in reduced expression of C3 and GFAP in hippocampal astrocytes. Additionally, global C1q deletion rescues synaptic density regardless of the age of deletion independent of amyloid phagocytosis.
Authors
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Shu‐Hui Chu (ORCID: https://orcid.org/0000-0003-3779-6412)
- Tiffany J. Petrisko (ORCID: https://orcid.org/0000-0003-4664-2853)
- Angela Gomez‐Arboledas
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104516
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00