Sex Differences in the Diffusion of Tau Neurofibrillary Tangles Across Functional Brain Networks
This study represents an in-depth investigation of tau diffusion, showing highest diffusion in the FPN and DMN, consistent with previous research on network-specific glucose metabolism. Additionally, higher tau diffusion in the LSN of females supports prior studies showing greater tau distribution in limbic regions of women.
Authors
- Y. Zhao
- Selena Wang (ORCID: https://orcid.org/0000-0002-4358-5382)
- Sujuan Gao (ORCID: https://orcid.org/0000-0002-6741-6380)
- Plamena P. Powla (ORCID: https://orcid.org/0000-0002-8226-2455)
- Tracy M. Sweet (ORCID: https://orcid.org/0000-0001-9929-7518)
- Yu‐Chien Wu
- Meichen Yu (ORCID: https://orcid.org/0009-0009-2228-1417)
- Andrew Joel Saykin
- Connor Lee Cornelison
- Theyaneshwaran Jayaprakash
- Li Shen
Institutions
- University of Indianapolis (US)
- Yale University (US)
- Indiana University Bloomington (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Maryland, College Park (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100019
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00