Antibodies raised against conformationally constrained Aβ β‐hairpins: Structural probes and potential immunotherapies

Monoclonal antibodies generated against conformationally constrained Aβ β-hairpins and oligomers are new tools for probing the structural landscape of Aβ in the brain. These antibodies offer the promise of new diagnostics and new avenues for AD therapies.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_099874
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Antibodies raised against conformationally constrained Aβ β‐hairpins: Structural probes and potential immunotherapies

Adam G. Kreutzer, James S. Nowick, Jovanna I. Carrera Plancarte, Jeff Dykstra
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Antibodies raised against conformationally constrained Aβ β‐hairpins: Structural probes and potential immunotherapies

Adam G. Kreutzer, James S. Nowick, Jovanna I. Carrera Plancarte, Jeff Dykstra
article en

Abstract

Monoclonal antibodies generated against conformationally constrained Aβ β-hairpins and oligomers are new tools for probing the structural landscape of Aβ in the brain. These antibodies offer the promise of new diagnostics and new avenues for AD therapies.

Alzheimer s & DementiaVol. 21(S1)
University of California, Irvine (US)
Good health and well-being
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
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