African‐origin protective haplotype for Alzheimer's disease in <i>APOEε4</i> carriers
Our results show that the protective haplotype locus of African origin has long-range, physical interactions with the APOE promoter and other regions on chr19. It also carries an expanded VNTR specific to the protective haplotype containing multiple transcription factor binding sites.
Authors
- Michael Cuccaro
- Juan I. Young
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Wanying Xu (ORCID: https://orcid.org/0009-0000-3262-2013)
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- Jeffery M. M Vance
- Regina Vontell (ORCID: https://orcid.org/0000-0002-2664-8265)
- D Van Booven
- David A. Davis (ORCID: https://orcid.org/0000-0002-9323-6180)
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Katalina McInerney
- Luciana Bertholim Nasciben
- Goldie S Byrd
- Margaret Pericak‐Vance
- ADSP (Alzheimer's Disease Sequencing Project)
- Jonathan L Haines
- Larry D Adams
- Farid Rajabli
- Sofia Moura
- Fulai Jin
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104916
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00