APOE4 astrocytes exhibit increased susceptibility to Aβ, tau, and cytokine‐induced mitochondrial dysfunction

This study provides experimental evidence of APOE4 linked mitochondrial dysfunction in astrocytes. APOE genotype differentially impacts mitochondrial health and bioenergetics in response to pathological stressors of AD. Future studies are warranted to assess the impact of astrocytic APOE4-associated mitochondrial dysfunction on pathogenic processes of AD in vivo.