Monoamine Oxidase‐B (MAO‐B) Identifies Neurotoxic Reactive Astrocytes in Alzheimer's Disease and Related Dementias
MAO-B up-regulation may identify the subset of reactive neurotoxic astrocytes in AD/ADRD. Multimodal PET-MRI studies are needed to test the hypothesis that MAO-B radioligand binding predicts future neurodegeneration in individuals with AD/ADRD.
Authors
- Neus Rabaneda‐Lombarte (ORCID: https://orcid.org/0000-0002-0781-4256)
- Alberto Serrano‐Pozo (ORCID: https://orcid.org/0000-0003-0899-7530)
- Methasit Jaisa-aad (ORCID: https://orcid.org/0000-0003-2994-2416)
- Teresa Gómez‐Isla (ORCID: https://orcid.org/0000-0002-7977-2075)
- Cinthya Agüero (ORCID: https://orcid.org/0000-0001-9483-429X)
- Alexandra Melloni (ORCID: https://orcid.org/0000-0002-0657-5919)
- Celia Bianco
- Bradley T. Hyman
- Pedro Brugarolas
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- MaineGeneral Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102019
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00