Association of cholinergic integrity measured by [ <sup>18</sup> F]‐fluoroethoxybenzovesamicol with age and amyloid burden in adults with Down syndrome
These data indicate an upregulation of cholinergic terminal markers in adults with DS by early adulthood, suggesting greater subsequent declines due to age and amyloid pathology relative to controls. Significant age and amyloid associations overlap in some regions, with more clusters exhibiting significant age-associated effects. This result suggests that declining regional [<sup>18</sup>F]-FEOBV uptake in adults with DS is influenced by both Alzheimer's-related pathology and aging, each playing distinct yet overlapping roles.
Authors
- Roger L. Albin (ORCID: https://orcid.org/0000-0002-0629-608X)
- John P. Begnoche (ORCID: https://orcid.org/0000-0001-6111-6662)
- Prabesh Kanel (ORCID: https://orcid.org/0000-0003-1418-2960)
- Michael S. Rafii (ORCID: https://orcid.org/0000-0003-2640-2094)
- Jason K Russell (ORCID: https://orcid.org/0000-0001-6263-1674)
- Alexander C. Conley (ORCID: https://orcid.org/0000-0003-1159-5524)
- PAUL A. NEWHOUSE (ORCID: https://orcid.org/0000-0002-9298-7185)
- Adam J. Rosenberg (ORCID: https://orcid.org/0000-0003-2459-7043)
- Brian D. Boyd (ORCID: https://orcid.org/0000-0002-2055-8154)
- Lealani Mae Y. Acosta (ORCID: https://orcid.org/0000-0002-3704-124X)
- Rachel Schlossberg
- Yasmeen Neal
- Allison Stranick
- Julie Dumas
- Dann Martin
Institutions
- University of Vermont (US)
- University of Southern California (US)
- Autism Research Institute (US)
- University of Michigan (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099363
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00