Fine Needle Aspiration of Thyroid Nodules: From Conventional Smears to Liquid‐Based Cytology—The 8‐Year Cleveland Clinic Abu Dhabi Experience

LBC is associated with several practical advantages over CS in thyroid cytology. In addition to streamlining and standardizing diagnostic workflows, it significantly helped to improve diagnostic accuracy. We observed a significant decrease in AUS rate, reducing interpretive uncertainty, and enhanced detection of malignancy with nuclear atypia. These findings validate Bethesda's recommendations for more granular classification of indeterminate cytology. The nondiagnostic rate increased slightly in the post-LBC period, a predictable effect of ROSE withdrawal. However, this modest rise was offset by the substantial gains in workflow efficiency and overall diagnostic accuracy achieved with LBC. This long-term experience reinforces LBC as a reliable and efficient method for thyroid FNA evaluation and better risk stratification.

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Publication Details

Journal
Diagnostic Cytopathology
Published
2025-12-23
DOI
https://doi.org/10.1002/dc.70072
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
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article

Fine Needle Aspiration of Thyroid Nodules: From Conventional Smears to Liquid‐Based Cytology—The 8‐Year Cleveland Clinic Abu Dhabi Experience

Ayoub Nahal
Diagnostic Cytopathology
Thyroid Cancer Diagnosis and Treatment
article

Fine Needle Aspiration of Thyroid Nodules: From Conventional Smears to Liquid‐Based Cytology—The 8‐Year Cleveland Clinic Abu Dhabi Experience

Ayoub Nahal
article en

Abstract

LBC is associated with several practical advantages over CS in thyroid cytology. In addition to streamlining and standardizing diagnostic workflows, it significantly helped to improve diagnostic accuracy. We observed a significant decrease in AUS rate, reducing interpretive uncertainty, and enhanced detection of malignancy with nuclear atypia. These findings validate Bethesda's recommendations for more granular classification of indeterminate cytology. The nondiagnostic rate increased slightly in the post-LBC period, a predictable effect of ROSE withdrawal. However, this modest rise was offset by the substantial gains in workflow efficiency and overall diagnostic accuracy achieved with LBC. This long-term experience reinforces LBC as a reliable and efficient method for thyroid FNA evaluation and better risk stratification.

Diagnostic CytopathologyVol. 54(3)
Cleveland Clinic Lerner College of Medicine (US), Case Western Reserve University (US)
Openalex Percentile: Top 30%
Thyroid Cancer Diagnosis and Treatment
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