White Matter Hyperintensities and Their Spatial Relationship to Mild Behavioral Impairment: Insights from Cluster‐Based Analysis

The association of MBI syndrome with increased WMH lesion volume suggests that cerebral small vessel disease may be involved in the emergence of MBI. The distinct lesion localization in posterior superior brain regions, areas involved in memory recollection, high-emotion processing, and goal-oriented behavior, emphasize the importance of spatially resolved WMH analyses in clarifying MBI's neurobiological basis.