LRRK2 Drives Synaptic Neurodegeneration via Tau Pathology and TREM2‐Dependent Microglial Activation in Alzheimer's Disease

This study suggests that CSF LRRK2 promotes Tau-associated synaptic neurodegeneration, and TREM2-related microglial activation may play an important role in this process.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_101030
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

LRRK2 Drives Synaptic Neurodegeneration via Tau Pathology and TREM2‐Dependent Microglial Activation in Alzheimer's Disease

J. Zhang, L F Wang, Weihua Yu, Ming Chen et al.
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
article

LRRK2 Drives Synaptic Neurodegeneration via Tau Pathology and TREM2‐Dependent Microglial Activation in Alzheimer's Disease

J. Zhang, L F Wang, Weihua Yu, Ming Chen, Yang Lü, Zehu Sheng
article en

Abstract

This study suggests that CSF LRRK2 promotes Tau-associated synaptic neurodegeneration, and TREM2-related microglial activation may play an important role in this process.

Alzheimer s & DementiaVol. 21(S1)
Zhongda Hospital Southeast University (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Chongqing Medical University (CN)
Openalex Percentile: Top 38%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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