Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren’s syndrome and identifies PS(36:1) as a potential therapeutic target
The multi-omics analysis conducted in this study enhances our understanding of the key regulatory mechanisms driving the pathogenesis of SS and offers novel insights for its precision therapy. Furthermore, PS(36:1) emerged as a potential therapeutic target for future SS research and treatment.
Authors
- Diqing Wu
- Yi Yang (ORCID: https://orcid.org/0000-0002-8247-7042)
- Jing Lu (ORCID: https://orcid.org/0000-0003-1549-574X)
- Zhenrong Hu
- Tianlin Lu
- Xudong Wang (ORCID: https://orcid.org/0000-0003-2320-9029)
- Fei Qian
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-1985-5485)
- Chaoran Li (ORCID: https://orcid.org/0000-0001-9517-8431)
- Ying Song
- Ningning Cao
- Zongze Shen
- Jingwen Yang
- Lijuan Zhu
- Yichao Xia
- Yeping Lu
- Yubo Xu
- Yanxiong Shao
- Tianyu Xiao
Institutions
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s12967-025-07361-x
- Citations
- 1
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 1.16