The Effects of Computerized Cognitive Training via Tablet and Computer Platforms on Cognitive Function in Patients with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

<b>Background:</b> Mild cognitive impairment (MCI) is a high-risk prodromal stage of dementia. While tablet/computer-based computerized cognitive training (CCT) is widely used, its efficacy and gamification's role need clarification. <b>Objective:</b> This study aimed to evaluate the effect of tablet/computer-based CCT on global cognition in older adults with MCI and explore the impact of gamification. <b>Methods:</b> We systematically searched five databases for RCTs (through October 2025) involving individuals aged ≥55 with MCI. The intervention was task-based CCT via tablets/computers. Primary outcome was global cognition. We used random-effects meta-analysis and subgroup analyses. <b>Results:</b> Nineteen RCTs (1013 participants) were included. CCT demonstrated a significant, moderate positive effect on global cognition (Hedges' g = 0.57, 95% CI [0.36, 0.78]). A trend suggesting greater benefits with higher gamification was observed: high (g = 0.71), medium (g = 0.46), and low (g = 0.45) degrees. However, subgroup differences were not statistically significant (<i>p</i> = 0.4333). Results were robust in sensitivity analyses. <b>Conclusions:</b> Tablet/computer-based CCT effectively improves global cognition in MCI. The potential additive value of gamification highlights its promise for enhancing engagement and effects, warranting further investigation in larger trials. This systematic review was registered with PROSPERO (CRD420251231618).