A single‐cell atlas of the aging human amygdala: a pilot study
Our pilot study demonstrated the feasibility of generating high-quality, large-scale single-cell multi-omic data from the human amygdala. We observed abundant AD-associated microglia in amygdala, suggesting the possibility that the regional vulnerability of amygdala to multiple neurodegenerative disorders might be in part due to different glial composition.
Authors
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- David H. Adamowicz (ORCID: https://orcid.org/0000-0002-4769-9096)
- Vladislav Petyuk (ORCID: https://orcid.org/0000-0003-4076-151X)
- Ling Teng
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Ya Zhang (ORCID: https://orcid.org/0000-0003-0894-4922)
- Jijing Wang
- Ryan Johnson
- Hyun‐Sik Yang
- Lei Liu
- Philip L. De Jager
- Zheng Yin
- Julie A Schneider
- David A. A. Bennett
- David W Gagliardi
Institutions
- Broad Institute (US)
- Rush University Medical Center (US)
- Harvard University (US)
- Pacific Northwest National Laboratory (US)
- Columbia University Irving Medical Center (US)
- Mass General Brigham (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104999
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00