Cholinergic White Matter Degeneration Could Help Identify Cognitively Unimpaired Elderly With Higher Plasma Ptau217

Our study extends previous findings by highlighting the potential of MRI-derived measures of NBM cholinergic white matter degeneration to capture the initial pathological events of elevated plasma ptau217. This may provide insights into the role of NBM cholinergic white matter degeneration in the preclinical identification of potential AD patients with Core 1 biomarker of plasma ptau217 before the occurrence of objective cognitive impairment.