Cell states associated with amyloid pathology and cognitive resilience in living human brain

NPH biopsies provide unique insights into cellular states associated with amyloid pathology and cognitive resilience. Integrating snRNA-seq from living and postmortem tissue bridges knowledge gaps in AD research, highlighting molecular and cellular changes underlying disease progression and resistance.

Authors

Evan Z. Macosko (ORCID: https://orcid.org/0000-0002-2794-5165)

Institutions

Broad Institute (US)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2025-12-01
DOI: https://doi.org/10.1002/alz70855_097567
Primary Topic: Single-cell and spatial transcriptomics
Type: article
Field-Weighted Citation Impact: 0.00

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article

Cell states associated with amyloid pathology and cognitive resilience in living human brain

Evan Z. Macosko

Dec 1, 2025

Alzheimer s & Dementia

Single-cell and spatial transcriptomics

article

Cell states associated with amyloid pathology and cognitive resilience in living human brain

Evan Z. Macosko

December 1, 2025article en

Abstract

Alzheimer s & DementiaVol. 21(S1)

Broad Institute (US)

Openalex Percentile: Top 36%

Single-cell and spatial transcriptomics

DOI Open Access PDF OpenAlex

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Cell states associated with amyloid pathology and cognitive resilience in living human brain — Evan Z. Macosko · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS