Overlapping Hepatic and Neurological Toxicity Following Intentional Multidrug Poisoning with Acetaminophen, Metoclopramide, and Metronidazole: A Case Report

This case highlights the diagnostic and therapeutic challenges of polydrug overdose with overlapping toxidromes. Rapid identification and agent-specific management, including NAC for APAP, symptomatic therapy for metoclopramide and metronidazole toxicity, and supportive care, resulted in full recovery without long-term sequelae. Emergency clinicians should maintain high suspicion for multiple co-ingestants and use targeted interventions to optimize outcomes.

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Publication Details

Journal
Clinical Medicine Insights Case Reports
Published
2025-12-01
DOI
https://doi.org/10.1177/11795476251410404
Citations
1
Primary Topic
Drug-Induced Hepatotoxicity and Protection
Type
article
Field-Weighted Citation Impact
1.56
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article

Overlapping Hepatic and Neurological Toxicity Following Intentional Multidrug Poisoning with Acetaminophen, Metoclopramide, and Metronidazole: A Case Report

Biruk Tesfahun Mengistie, Chernet T. Mengistie, Ayenew A. Wolie, Elsabet A. Alebachew et al.
1 citations
Clinical Medicine Insights Case Reports
Drug-Induced Hepatotoxicity and Protection
1.56
article

Overlapping Hepatic and Neurological Toxicity Following Intentional Multidrug Poisoning with Acetaminophen, Metoclopramide, and Metronidazole: A Case Report

Biruk Tesfahun Mengistie, Chernet T. Mengistie, Ayenew A. Wolie, Elsabet A. Alebachew, Selamawit M. Bonus, Sabontu A. Wakie, Ayenew Genet
article en
1 citations

Abstract

This case highlights the diagnostic and therapeutic challenges of polydrug overdose with overlapping toxidromes. Rapid identification and agent-specific management, including NAC for APAP, symptomatic therapy for metoclopramide and metronidazole toxicity, and supportive care, resulted in full recovery without long-term sequelae. Emergency clinicians should maintain high suspicion for multiple co-ingestants and use targeted interventions to optimize outcomes.

Clinical Medicine Insights Case ReportsVol. 18
Addis Ababa University (ET)
Good health and well-being
Openalex Percentile: Top 13%
Drug-Induced Hepatotoxicity and Protection
1.56
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