Overlapping Hepatic and Neurological Toxicity Following Intentional Multidrug Poisoning with Acetaminophen, Metoclopramide, and Metronidazole: A Case Report
This case highlights the diagnostic and therapeutic challenges of polydrug overdose with overlapping toxidromes. Rapid identification and agent-specific management, including NAC for APAP, symptomatic therapy for metoclopramide and metronidazole toxicity, and supportive care, resulted in full recovery without long-term sequelae. Emergency clinicians should maintain high suspicion for multiple co-ingestants and use targeted interventions to optimize outcomes.
Authors
- Biruk Tesfahun Mengistie (ORCID: https://orcid.org/0009-0005-4647-111X)
- Chernet T. Mengistie (ORCID: https://orcid.org/0009-0009-0061-6458)
- Ayenew A. Wolie (ORCID: https://orcid.org/0009-0003-3667-2458)
- Elsabet A. Alebachew
- Selamawit M. Bonus
- Sabontu A. Wakie
- Ayenew Genet
Institutions
- Addis Ababa University (ET)
Publication Details
- Journal
- Clinical Medicine Insights Case Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1177/11795476251410404
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56