Longitudinal T-Cell Phenotypic Dynamics During Sustained Antiretroviral Therapy in People With HIV
Long-term ART promotes partial immune normalization, including reduced activation and reversal of CD4⁺ T-cell exhaustion. However, persistent expression of CD8⁺ T-cell surrogate markers of exhaustion and stable cytotoxic profiles suggest ongoing antigenic stimulation, potentially driven by HIV or chronic coinfections.
Authors
- Victor DeGruttola (ORCID: https://orcid.org/0000-0003-2772-6242)
- Noah C. Gaitan (ORCID: https://orcid.org/0009-0001-8413-3497)
- Eileen P. Scully (ORCID: https://orcid.org/0000-0002-6687-6051)
- Alan Landay (ORCID: https://orcid.org/0000-0001-9645-1356)
- Antoine Chaillon (ORCID: https://orcid.org/0000-0001-9490-3857)
- Miranda L. Lynch (ORCID: https://orcid.org/0000-0001-8604-4431)
- Brendon Woodworth (ORCID: https://orcid.org/0000-0003-3412-0396)
- Jonathan Karn (ORCID: https://orcid.org/0000-0002-2900-094X)
- Stephen A. Rawlings (ORCID: https://orcid.org/0000-0003-3637-1447)
- A. F. Wells
- Sara Gianella (ORCID: https://orcid.org/0000-0002-9927-0849)
- Christophe Guy Éric Vanpouille
- Xinlian Zhang (ORCID: https://orcid.org/0000-0002-0913-1205)
- Kathleen M Weber
- Xin Tu
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of California San Diego (US)
- Hektoen Institute (US)
- Human Longevity (United States) (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- The University of Texas Medical Branch at Galveston (US)
- Case Western Reserve University (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1093/ofid/ofaf775
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00