Synaptic protein expression remodeling in the LOAD2 mouse model
The MODEL-AD Center has developed mouse models with humanized genetic risk factors to better study the progression of late-onset Alzheimer's disease (LOAD). Our findings demonstrate that the synaptic protein alterations in the LOAD2 mouse model, closely resemble the synaptic signatures observed in AD pathology.
Authors
- Abigail Perkins (ORCID: https://orcid.org/0000-0001-7562-1635)
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Claudia Rangel‐Barajas (ORCID: https://orcid.org/0000-0002-4818-8247)
- Adrian L Oblak
- Dalia Elkhatib
- Cinthia Ingraham
- Bruce T. Lamb
- Gregory W Carter
- Christopher D Lloyd
Institutions
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102380
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00