Hippocampal Microstructure as a Measure of Cognitive Resilience to Early Braak Staged Tau PET burden in Dementia‐free older adults

These findings suggest that better hippocampal microstructure may be a sensitive biomarker of cognitive resilience, by partially mitigating the adverse relationship between greater tau burden and poorer cognition. Unlike volumetric measures, diffusion-weighted imaging metrics may offer valuable insights into brain mechanisms and hold promise as outcome measures for early interventions to preserve cognitive function in AD.