Evaluating neurotoxicity and AD‐related molecular phenotypes to anticholinergic medications in hiPSC‐derived neurons from the ACT cohort

Our findings reveal that antidepressants and bladder antimuscarinic drugs consistently induce neurotoxicity and pathogenic amyloid-beta peptide secretion without affecting tau phosphorylation. Our study validates the direct correlation between increased dementia risk and the action of antidepressant and bladder antimuscarinic drugs and provides molecular insights into how these drugs induce neuronal dysfunction contributing to AD development.