Representing the Cognitive Impairment Continuum of Alzheimer's Disease and Lewy Body Dementia with a Novel Finer‐Scale Cortical Representation via Disease Embedding Tree
The DET framework effectively models the continuous relationships among CN, AD, and LBD subjects and outperforms the traditional models in the classification task. By leveraging cortical features of the cortical hubs and the MMSE-based constraints, it provides valuable insights into disease progression.
Authors
- T. Liu
- O'Brien John Tiernan
- Tong Chen (ORCID: https://orcid.org/0000-0002-2715-5278)
- Dajiang Zhu (ORCID: https://orcid.org/0000-0001-6579-5148)
- Andrew M. Blamire (ORCID: https://orcid.org/0000-0002-8749-1257)
- Li Su (ORCID: https://orcid.org/0009-0001-8976-8512)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-2494-8077)
- Minheng Chen (ORCID: https://orcid.org/0009-0009-3926-9289)
- Yan Zhuang
- Lu Zhang
Institutions
- University of Georgia (US)
- The University of Texas at Arlington (US)
- University of Cambridge (GB)
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
- Newcastle University (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102179
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00