Understanding and targeting neuropsychiatric symptoms in aging, Alzheimer's, and throughout menopause

These findings suggest that Neuropsychiatric symptoms impact cognitive decline through sex-specific pathways in the hippocampus and that benzodiazepines may not be beneficial when treating Alzheimer's disease patients. Menopause can also induce this earlier anxiety-like phenotype, but the brain may compensate for these hormonal changes. Future studies will examine the impact of chronic BZD use on aging and Alzheimer's disease.