SpatialE identifies spatial enrichment of Alzheimer's Disease and Amyotrophic Lateral Sclerosis genes in human brain
We developed a novel computational tool (SpatialE) to characterize spatial enrichment expression of a gene set in spatial transcriptomics data. Spatial enrichment analyses identified regional brain vulnerability of AD and ALS associated genes in human brain.
Authors
- Ming Zhang (ORCID: https://orcid.org/0000-0002-4491-8927)
- Linya You (ORCID: https://orcid.org/0000-0002-2569-0269)
- Jingyan Guo
- Yan Chen
Institutions
- Tongji University (CN)
- Fudan University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100010
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00