Molecular and clinical stratification of astroblastomas: Three distinct fusion-defined groups informing risk-adapted treatment strategies
Astroblastoma, MN1-altered, comprises three molecularly and clinically distinct groups, characterized by different fusion genes, including those without MN1. These new insights, including identification of potential predictive biomarkers like 14q/16q loss, provide a framework for development of risk-stratified therapeutic approaches. Importantly, we identified a molecularly defined high-risk group that benefits from radiation therapy. Our findings redefine Astroblastoma as a molecularly diverse tumor type, propose a refined classification, support the development of risk-adapted therapeutic strategies and provide a rational standard of care.
Authors
- Vijay Ramaswamy
- Aditya Raghunathan (ORCID: https://orcid.org/0000-0001-6198-7441)
- R. Packer
- Christof M. Kramm (ORCID: https://orcid.org/0000-0002-5017-926X)
- Lorena Baroni (ORCID: https://orcid.org/0000-0002-1599-7080)
- Adriana Fonseca (ORCID: https://orcid.org/0000-0002-6382-6833)
- Barbara Aistleitner
- Jens Bunt (ORCID: https://orcid.org/0000-0003-0397-2019)
- Yelena Wilson (ORCID: https://orcid.org/0000-0003-1725-0041)
- Jordan R. Hansford (ORCID: https://orcid.org/0000-0001-7733-383X)
- Martin Sill
- Daniel Schrimpf (ORCID: https://orcid.org/0000-0003-3063-2423)
- Johannes Gojo (ORCID: https://orcid.org/0000-0002-8113-3416)
- Felix Schmitt-Hoffner (ORCID: https://orcid.org/0000-0003-1774-1035)
- Mariëtte E.G. Kranendonk (ORCID: https://orcid.org/0000-0001-9683-7494)
- Lauren Weintraub (ORCID: https://orcid.org/0009-0009-4406-1255)
- Stefan M. Pfister (ORCID: https://orcid.org/0000-0002-5447-5322)
- Zied Abdullaev (ORCID: https://orcid.org/0000-0001-6345-2088)
- Katharina Bruckner (ORCID: https://orcid.org/0000-0002-6633-4009)
- Andreas von Deimling (ORCID: https://orcid.org/0000-0002-5863-540X)
- Natalie Jäger
- J. Koster
- Maria Łastowska (ORCID: https://orcid.org/0000-0003-0632-6995)
- Andrew M. Donson (ORCID: https://orcid.org/0000-0003-1153-6911)
- Florian Selt (ORCID: https://orcid.org/0000-0001-9717-6712)
- Pascale Varlet (ORCID: https://orcid.org/0000-0002-8164-1517)
- Jasper van der Lugt (ORCID: https://orcid.org/0000-0002-8186-338X)
- Dominik Sturm
- M. Kool
- Monika Mauermann
- Aniello Federico
- Damian Stichel
- Evelina Miele
- Christine Haberler
- Ulrich Schüller
- Barbara C. Jones (ORCID: https://orcid.org/0009-0003-9087-6013)
- Prof Felix Sahm
- Sabine Spiegl-Kreinecker
- Mimi Kjaersgaard
- Manila Antonelli
- Kenneth Aldape
- Neal Geisemeyer
- Arnault Tauziede-Espariat
- Katja Von Hoff
- Matija Snuderl
- David Capper
- Lane Williamson
- Michal Zapotocky
- Andrey Korshunov
- Sebastian Brandner
- Alexandra Kolenova
Institutions
- Johannes Kepler University of Linz (AT)
- Royal Children's Hospital (AU)
- Mayo Clinic (US)
- Children's National (US)
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Utrecht University (NL)
- Charles University (CZ)
- Heidelberg University (DE)
- Garrahan Hospital (AR)
- Women's and Children's Hospital (AU)
- Hospital for Sick Children (CA)
- University Hospital Heidelberg (DE)
- Aarhus University Hospital (DK)
- Rigshospitalet (DK)
- Istituto Neurologico Mediterraneo (IT)
- University Medical Center Utrecht (NL)
- Humboldt-Universität zu Berlin (DE)
- Comprehensive Cancer Center Vienna (AT)
- Morgan Adams Foundation (US)
- University Hospital in Motol (CZ)
- Akron Children's Hospital (US)
- Amsterdam Neuroscience (NL)
- University Medical Center Hamburg-Eppendorf (DE)
- Kinderkrebs-Zentrum Hamburg (DE)
- National Center for Tumor Diseases (DE)
- Children's Memorial Health Institute (PL)
- Hopp Children's Cancer Center Heidelberg (DE)
- Nephrologisches Zentrum Goettingen (DE)
- Kepler Universitätsklinikum (AT)
- Bambino Gesù Children's Hospital (IT)
- Centre Hospitalier Sainte-Anne (FR)
- Mayo Clinic in Arizona (US)
- Princess Máxima Center (NL)
- South Australian Health and Medical Research Institute (AU)
- Centre for Cancer Biology (AU)
- National Cancer Institute (US)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University College London (GB)
- New York University (US)
- Comenius University Bratislava (SK)
- Medical University of Vienna (AT)
- Albany Medical Center Hospital (US)
- Charité - Universitätsmedizin Berlin (DE)
- Heidelberg University (US)
- Sapienza University of Rome (IT)
- University of Amsterdam (NL)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1093/neuonc/noaf283
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25