Changes in Phosphorylation of the TREM2‐PLCG2 Signaling Pathway Components Influences Microglia Function

We discovered that stimulation of TREM2 in microglia led to a novel signalling cascade involving PLCG2 and other proteins which mediated important microglia functions. Some of these proteins are components of the B cell receptor signaling machinery acting via PLCG2 while others are known/new AD-related risk genes. The elucidation of the TREM2-PLCG2 pathway and its downstream signalling partners provides important insights into the mechanisms of normal microglia function and in the pathogenesis of AD.