<i>APOE4</i> to <i>APOE2</i> ‘Switching’ in the CNS vs Periphery: Differential Effects on AD Neuropathology
Together, these data suggest that while either an astrocyte- or microglia-specific E4 to E2 replacement is sufficient to mitiage amyloid pathology, the cellular response to AD pathology differs substantially depending on the cell type targeted. Overall, this proof of concept data provides insight that will be valuable for guiding development of future APOE directed therapies.
Authors
- Lance A. Johnson (ORCID: https://orcid.org/0000-0003-0134-7586)
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100273
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00