Networks of age‐related pathologies and APOE ε4: their role in hippocampal degeneration
Hippocampal damage in age-related dementias is multifactorial, extending beyond the contributions of Aβ and tau, with LATE-NC playing a central role. APOE ε4 indirectly influences hippocampal degeneration by promoting Aβ-related pathogenesis and triggering interactions among comorbid pathologies that drive neuronal loss.
Authors
- Estifanos Ghebremedhin
- Alicja Ronisz (ORCID: https://orcid.org/0000-0002-4310-0445)
- Klara Gawor (ORCID: https://orcid.org/0000-0001-7571-5420)
- Dietmar Rudolf Thal (ORCID: https://orcid.org/0000-0002-1036-1075)
- Simona Ospitalieri
- D. J. Wouters (ORCID: https://orcid.org/0000-0002-8000-8023)
- Geethika Arekatla (ORCID: https://orcid.org/0009-0002-2639-9964)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Sandra O. Tomé (ORCID: https://orcid.org/0000-0001-5253-0730)
- Celeste Laureyssen (ORCID: https://orcid.org/0000-0002-7373-2099)
- Sam Verrept (ORCID: https://orcid.org/0009-0001-0918-7890)
- Helena Ver Donck
- Bas Lahaije (ORCID: https://orcid.org/0009-0001-5887-6844)
- Alejandro Sifrim
- Kristel Sleegers
- Christine A.F. von Arnim
- Rik Vandenberghe
- Mathieu Vandenbulcke
Institutions
- Goethe University Frankfurt (DE)
- Universitair Ziekenhuis Leuven (BE)
- VIB-KU Leuven Center for Microbiology (BE)
- Universitätsmedizin Göttingen (DE)
- VIB-UAntwerp Center for Molecular Neurology (BE)
- Neuroelectronics Research Flanders (BE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Martin Luther University Halle-Wittenberg (DE)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103205
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00