Polysaccharide extract of <i>Hedysarum alpinum</i> exhibits neuroprotective effects in an Alzheimer's disease model mice and suppresses inflammation in LPS‐induced RAW264.7 macrophages
Our findings demonstrate that HAP significantly reduces inflammation and improves cognitive function in 5xFAD mice. These beneficial effects could be mediated through the modulation of the microbiota-gut-brain axis, which will be further elucidate through analyzing of the gut microbiome composition.
Authors
- Chun‐Yen Yang (ORCID: https://orcid.org/0000-0003-3941-4561)
- Aldarmaa Jalsrai
- Hsiu‐Mei Hsieh
Institutions
- National Taiwan Normal University (TW)
- New Mongol Institute of Technology (MN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101570
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00