Microglia Expressing the Alzheimer's Disease Protective Variant <i>PLCG2</i> ‐P522R Suppress the NLRP3 Inflammasome
PLCG2-P522R reduces NLRP3 inflammasome activation in microglia. This potentially contributes to the P522R variant's association with decreased AD risk. Furthermore, our novel flow cytometry paradigm for quantifying secreted ASC specks provides a valuable tool for studying inflammasome activity. These results support the development of NLRP3-targeted therapeutics for AD that mimic the neuroprotective effects of P522R.
Authors
- Matthew P. Sadgrove
- Anuragh Krishna Sriram
- Gwenn A Garden
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100639
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00