Sparse machine learning of resting-state fMRI reveals brain-wide dysconnectivity in hyperacusis
Through rigorous data-driven modeling, we characterize the reduced sound tolerance condition of loudness hyperacusis as being associated with atypical spontaneous connectivity across cognitive networks that extend beyond the auditory system. Such improved knowledge of the condition validates patient experiences and has implications for future treatments and assessments.
Authors
- Rafay A. Khan (ORCID: https://orcid.org/0000-0002-6146-5800)
- Shagun Ajmera (ORCID: https://orcid.org/0000-0001-5008-2161)
- Howard Berenbaum (ORCID: https://orcid.org/0000-0003-4610-2195)
- Fatima T. Husain (ORCID: https://orcid.org/0000-0001-5878-3851)
- Gibbeum Kim (ORCID: https://orcid.org/0000-0001-5057-9258)
- Namitha Jain
- Ariana Andrea Castro (ORCID: https://orcid.org/0000-0002-7091-2166)
Institutions
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1038/s43856-025-01313-8
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Illinois at Urbana-Champaign
- Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign