Cadmium exposure accelerates cognitive deficits and Alzheimer's disease progression in 5xFAD mice
Our studies demonstrate that chronic exposure to Cd or Pb can exacerbate cognitive deficits and AD progression in 5xFAD mice. Mechanistically, we discovered that Cd exposure-induced acceleration of AD progression was associated with increased levels of senescent cell burden and neuroinflammation in the hippocampus.
Authors
- Steven Grant Dixon
- Steven L. Carroll (ORCID: https://orcid.org/0000-0001-6714-4373)
- Gavin Y. Wang
- Maxwell Cook (ORCID: https://orcid.org/0000-0002-1151-1805)
Institutions
- Medical University of South Carolina (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103810
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00