Investigating the effects of NOTCH3 Asian‐specific mutant on blood‐brain‐barrier using patient iPSC‐derived cell types
Our findings show that the effects of NOTCH3 MT is multi-faceted, affecting multiple cell types, calling for the need to study them in a heterogenous model. Ultimately, unravelling effects of vascular deregulation in CADASIL will contribute to understanding its disease pathophysiology.
Authors
- Eng‐King Tan (ORCID: https://orcid.org/0000-0003-2977-9743)
- Adeline Su Lyn Ng
- Li Zeng (ORCID: https://orcid.org/0000-0002-9039-6509)
- Jolene Wei Ling Lee
Institutions
- Duke-NUS Medical School (SG)
- National Neuroscience Institute (SG)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106310
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00