Aberrant Protein S‐Palmitoylation: A Novel Therapeutic Target in Alzheimer's Disease
These findings indicate that aberrant S-palmitoylation plays a critical role in the synaptic dysfunction and cognitive impairments observed in AD. Targeting zDHHC enzymes represents a novel and promising therapeutic approach to address cognitive decline in AD patients by mitigating pathological S-palmitoylation.
Authors
- Ida Nifo Sarrapochiello (ORCID: https://orcid.org/0000-0002-8367-6289)
- Salvatore Fusco (ORCID: https://orcid.org/0000-0003-3294-0016)
- Giuseppe Aceto (ORCID: https://orcid.org/0000-0002-7530-6835)
- Matteo Spinelli (ORCID: https://orcid.org/0000-0001-5776-988X)
- Francesca Natale (ORCID: https://orcid.org/0000-0001-7856-930X)
- Claudio Grassi
- Daniela Puzzo
- Marco Rinaudo
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Sassari (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of Catania (IT)
- Oasi Maria SS (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102201
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00